Difficulty switching behavioral response sets is established in psychotic disorders. In rodent models, prefrontal lesions cause difficulty initially switching to new response sets (perseverative errors) while striatal lesions cause difficulty suppressing responses to previous choice preferences (regressive errors).

Hill SK, Reilly JL, Ragozzino ME, Rubin LH, Bishop JR, Gur RC, Gershon ES, Tamminga CA, Pearlson GD, Keshavan MS, Keefe RSE, Sweeney JA. Regressing to prior response preference after set switching implicates striatal dysfunction across psychotic disorders:  Findings from the B-SNIP study.  Schizophrenia Bulletin, September 5, 2014 [epub ahead of print].