Chronic schizophrenic patients with the most severe social deterioration have been shown to differ from other chronic schizophrenic patients with respect to measures of left-to-right ventricular asymmetry, negative symptoms, and response to haloperidol treatment. In the current study, the authors investigated the social antecedents of these characteristics of very poor outcome schizophrenia in 69 chronic schizophrenic patients.

Keefe RSE, Mohs RC, Losonczy MF, Davidson M, Silverman JM, Horvath TB, Davis KL.  Premorbid sociosexual functioning and long-term outcome in schizophrenia. American Journal of Psychiatry, 1989; 146(2): 206-211.