Multisite clinical trials aimed at cognitive enhancement across various neuropsychiatric conditions have employed standard neuropsychological tests as outcome measures. While these tests have enjoyed wide clinical use and have proven reliable and predictive of functional disability, a number of implementation challenges have arisen when these tests are used in clinical trials.

Keefe RSE, Harvey PD. Implementation considerations for multi-site clinical trials with cognitive neuroscience tasks.  Schizophrenia Bulletin, 2008; 34(4): 656-663.  PMCID: PMC2632463.