Cognition is affected by circadian rhythms over the course of a day. Circadian rhythms in cognitive functioning are driven by a variety of both endogenous and exogenous factors. Patients with schizophrenia are known to have disturbed circadian rhythms that can affect their cognitive functioning.

  1. Hufford MR, Davis VG, Hilt D, Dgetluck N, Geffen Y, Loebel A, Haig G, Santarelli L, Keefe RSE. Circadian rhythms in cognitive functioning among patients with schizophrenia: impact on signal detection in clinical trials of pro-cognitive therapies.  Schizophrenia Research, 2014; 159(1): 205-210.